SAN FRANCISCO -- Wideout Mario Manningham will not play in the 49ers' regular-season home finale against the Atlanta Falcons and instead be replaced in the receiving corps by rookie Quinton Patton, who hasn't suited up since fracturing his right foot Oct. 26 at St. Louis.
Left guard Mike Iupati is slated to start in his return from a four-game absence that was due to a sprained knee. Also active is tight end Vance McDonald, who missed last Sunday's win at Tampa Bay because of an ankle issue.
Manningham missed two days of practice last week because of an illness and lingering knee soreness. In the past three games, he has had only one pass thrown his way, and he caught it for a 2-yard gain. He has nine receptions for 85 yards in six games since returning from a December 2012 knee injury.
Patton made only one reception in the first four games before sustaining his foot injury.
The 49ers' other inactives are wideout Jon Baldwin, tight end Derek Carrier, linebacker Nick Moody, defensive tackle Quinton Dial and guards Joe Looney and Ryan Seymour.