Running back LaMichael James is suiting up for the first time his rookie season. Meanwhile, two other prominent first-year 49ers (and ex-Giants) are not suiting up: running back Brandon Jacobs and wide receiver Mario Manningham.
James was inactive for the 49ers' first 12 games and hasn't been seen in uniform since sustaining an ankle injury during an Aug. 18 exhibition at Houston.
The 49ers drafted James in the second round out of Oregon, where he set program records while running for 5,082 yards and 53 touchdowns.
Wide receiver A.J. Jenkins, the 49ers' first-round draft pick this season, will be active for the third time and is expected to see his first snaps. He didn't play last Sunday at St. Louis nor in the season opener at Green Bay, the other two games he's been active.
Also inactive for the 49ers are quarterback Scott Tolzien, guard Joe Looney, nose tackle Ian Williams, safety Trenton Robinson and running back Jewell Hampton.
Inactive for the Dolphins are quarterback Pat Devilin, safety Jimmy Wilson, cornerback Michael Coe, linebacker Josh Kaddu, tackle Patrick Brown, tight end Michael Egnew and tight end Kyle Miller.
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Jacobs' benching shouldn't be too surprising. He turned to social media again this weekend to vent his frustration over a lack of playing time. Jacobs' only action this season came in the past two games: five carries for 7 yards.
Jacobs has ranted on Twitter often this season
That remark prompted angry retorts from 49ers fans, to which Jacobs replied through Twitter: "I don't understand why people are angry at me because I wanna do what I am paid to do, I am a competitive person, I think people should be mad if I didn't wanna play, but I forgot the people that's pissed they don't have a athletic bone and their body. As for all of my Instagram photos I don't have any niner pics, if you'll find me some pics I'll put them up."
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Manningham did not practice Wednesday through Friday because of a shoulder injury he aggravated in last Sunday's loss at St. Louis.