Major League Baseball says it is "extremely disappointed" about a new report that says records from an anti-aging clinic in the Miami area link Alex Rodriguez, Melky Cabrera, Bartolo Colon, Gio Gonzalez and other players, to the purchase of performance-enhancing drugs.

The Miami New Times said in a story Tuesday that it had obtained files through an employee at a recently closed clinic called Biogenesis.

Colon, who was suspended for 50 games for testing positive for PEDs last season with the A's, re-signed with Oakland in the offseason. Cabrera, a former Giants All-Star, was also suspended for 50 games last year and has since signed with Toronto.

Gonzalez, a former A's pitcher, won 21 games for the Washington Nationals in 2012. The Washington Times reported that Gonzalez issued a denial through his representatives, saying "I've never used performance-enhancing drugs of any kind, and I never will. I've never met or spoken with (Biogenesis owner) Tony Bosch or used any substances provided by him. Anything said to the contrary is a lie."

MLB responded to Tuesday's news with a statement that says "through our Department of Investigations, we have been actively involved in the issues in South Florida." The unsigned statement also says "we are always extremely disappointed to learn of potential links between players and the use of performance-enhancing substances."

Also included on the list of players mentioned is Rangers outfielder Nelson Cruz.

Rodriguez has admitted using steroids from 2001-03 but insisted he stopped after that.