Nationwide, at least 22 physicians have made more than $500,000 since 2009 giving talks and consulting for drugmakers, an updated database shows.

Overall the companies spent $2 billion in those years. Roughly half the reported payments were for research. A third went to speakers and the rest went to consulting, travel, meals and related expenses.

California, the nation's most populous state, topped the list of states receiving the most drug company money. Wyoming, with less than a half-million dollars, was last on the spending list.

Top five states receiving drug company money, 2009-2012, in millions of dollars.

California -- $241.8

Florida -- 168.7

Texas -- 161.2

New York -- 142.1

Pennsylvania -- 97.1

Bottom five receiving the least money from drug companies, in millions of dollars.

Hawaii -- $3.2

South Dakota -- 3.1

Montana -- 2.7

Vermont -- 1.8

Wyoming -- 470,000

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