Gilroy's Robert "Ghost" Guerrero is convinced unbeaten Floyd Mayweather will take him seriously when they square off for the WBC welterweight world championship bout on May 4 in Las Vegas.

"That's not going to make a difference because I know his body's soft," Guerrero said Wednesday during a media teleconference. "Being a whole year layoff, he's going to feel the punches different."

Mayweather hasn't fought since spending two months in jail last summer for a misdemeanor domestic violence case involving an ex-girlfriend.

Guerrero (31-1-1, 18 KOs) called the bout at the MGM Grand Garden Arena "the opportunity of a lifetime."

"God put him in front of me for a reason and I'm going to beat him," said the 30-year-old six-time, five-division world champion. "Floyd Mayweather having a year off and being in jail, it takes a toll on you. No matter what you do, you do have a little ring rust."

Mayweather (43-0-0, 26 KOs), making a mandatory defense of his WBC crown, said he's amused listening to Guerrero.

"He's a solid opponent," said Mayweather, 36, one of history's greatest pound-for-pound fighters. "When I'm watching him talk, he's funny to me. You get a different Robert Guerrero when he's in front of me. When we finally met up face to face, he had nothing to say."

The layoff won't pose any difficulty, said Mayweather, who has fought only four times the past four years.

"This is not my first time taking a year off, not my first time taking a couple years off. I just call it a vacation," he said. "The body needs time to recuperate, the body needs time to rest."

Mayweather, an eight-time, five-division champion, said nothing Guerrero presents, including being a left-hander, will be an issue. "Last time I looked, I was 43-0," he said.

Guerrero said preparation for the biggest fight of his career hasn't been distracted by his March 28 arrest on suspicion of gun possession at New York's John F. Kennedy Airport. He faces a May 14 court date.

"Nah, I'm ready to go," he said. "There ain't nothing stopping me from winning this fight. All the focus is there. I'm ready to go. That's the bottom line."

Guerrero declined to answer any additional questions related to the incident.

But on the most recent episode of Showtime Sports' "All Access" program promoting the bout, Mayweather labeled Guerrero, who considers himself a strong Christian, as a "hypocrite" in the wake of the gun charge.

"We're all hypocrites," Guerrero answered. "If you're a perfect person, you wouldn't need Jesus Christ. Just shows how much he keeps his head in the Bible. It's laughable."

Mayweather said his complaint is that Guerrero has characterized him as having his priorities out of whack.

"He's (said) money is my god and I praise money," Mayweather said of comments he attributed to Guerrero.

In June 2012, Forbes magazine listed Mayweather as the world's highest-paid athlete, with earnings of $85 million over the previous year. And his own promotions company markets him as Floyd "Money" Mayweather.

Still, Mayweather said that's not all he's about.

"He believes in God. I believe in God. This is not about religion," Mayweather said. "This is about two fighters going out there, testing their skills against each other."

Guerrero has campaigned a couple years for this fight and Mayweather acknowledged his manager presented the matchup to him a year ago. "I didn't know who he was a year ago," Mayweather said. "I probably heard his name in passing."

No one in the sport hasn't heard of Mayweather.

"This is the guy. He's the man to beat," Guerrero said. "You beat him, you're on top. We had to really push hard, wanting the fight bad to be the best in boxing."