According to the Oxalosis & Hyperoxaluria Foundation (OHF), Primary Hyperoxaluria is a rare genetic inherited disorder that is present at birth and comes in different forms. Type I affects an estimated 1 in 100,000 to 1 in 1 million people.

In Type I, "the liver creates too little of the enzyme alanine: glyoxylate aminotransferase or AGT. The (enzyme) deficiency causes increased amounts of oxalate and glycolate to be formed in the body ... which cannot be metabolized," according to the foundation's website.

Typical symptoms include kidney stones, which some people may develop as early as birth but most by their mid-20s. The kidneys can be irreparably damaged when excessive amounts of oxalates are present in the urine, and sometimes kidney failure is the first clue that someone has the disease, according to OHF.

"Oxalosis occurs after the kidneys fail and the excess oxalate builds up in the blood and then deposits oxalate salts in the eyes, blood vessels, bones, muscles, heart and other major organs, according to OHF.

Source: www.ohf.org



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