Robert Ramirez, 49, of Rancho Cucamonga was taken into custody near Highland Springs Road and 2nd Street in Beaumont by the San Bernardino County sheriff's Specialized Enforcement Division.
Deputies responded at about 10:48 p.m. Tuesday to the condominium shared by Ramirez and his wife in the 8000 block of Tulsa Place in Rancho Cucamonga after neighbors complained about an argument at the house.
Pamela Ramirez, 48, was found suffering from apparent stab wounds, according to a sheriff's news release.
Paramedics pronounced her dead at the scene.
Detectives determined that an argument between the married couple had become violent.
The couple were the only people with access to the residence and Robert Ramirez had fled the scene, according to the news release.
The investigation is ongoing.
Anyone with information regarding this incident can call Detective Mauricio Hurtado or Sgt. Trevis Newport of the sheriff's Homicide Division at 909-387-3589.
Callers wishing to remain anonymous are urged to contact the We-Tip hotline at 1-800-78-Crime.
Information can also be left at www.wetip.com.