Starting Dec. 12, Megabus.com will start running buses to Las Vegas, San Francisco and Oakland. The buses headed north also will make a stop in San Jose, and those headed for Las Vegas will make a stop in Riverside.
Buses will leave from Union Station's Patsaouras Transit Plaza.
Megabus.com, a subsidiary of Coach USA, operated in Los Angeles for about a year, starting in 2007, but ended its service because of a lack of demand.
Mike Alvich, the vice president of marketing and public relations, said he was confident Megabus.com would be a success this time around, in part because it offers "double-decker buses with WiFi and power outlets."
Megabus.com operates on a model similar to Southwest Airlines, Alvich said. Fares booked 30-45 days in advance can go for as cheap as $1. Tickets bought closer to the departure date will be more expensive -- up to $40 for some trips, depending on demand.
To drum up interest in the service, Megabus is guaranteeing $1 fares on all travel Dec. 12-19.
"As California residents continue to look for ways to stretch their dollar, megabus.com is committed to safe, affordable travel during this holiday season and beyond," Alvich said.
The company estimates it will handle about 247,000 customers in the Los Angeles area over the coming year.
The expansion will create more than 80 new jobs, according to Megabus.com.