Powell, who struggled with foot problems last year, scored a career-high 29 points in helping Stanford beat Denver 71-58 Sunday.
Powell helped the Cardinal (6-3) dominate in the paint, where Stanford outscored the Pioneers 36-20.
"One of our focuses has been to use our size," Powell said. "Hit the post, look for the cutters and try to get some easy shots."
Powell finished 10 of 13 from the field and made 9 of 11 free throws.
"He's still developing but we're beginning to figure out what we'll get from him every night and he's starting to find that consistency," Cardinal coach Johnny Dawkins said. "He showed flashes as a freshman and now I think we'll be seeing more games like this from him."
Josh Huestis grabbed a game-high 10 rebounds, his second double-figure rebounding game of the year. He's averaging a team best 8.1.
Royce O'Neale scored 17 points for the Pioneers (1-5), who lost their fourth straight.
"This is another big part of the challenge," Denver coach Joe Scott said. "I thought in the second half we executed extremely well. When we execute that way, when that becomes who we are, we're going to be a good basketball team."
Stanford, which now begins a 13-day break for finals, never trailed against the Pioneers. The Cardinal built an early 21-6 advantage and Denver, which has not
"It was a good game for us going into the break," Dawkins said. "We had to learn how to deal with their unorthodox defense. We made some shots and guys are growing into their roles."
Chris Udofia added 10 points for the Pioneers, who have not beaten Stanford since 1972 and have lost five straight. Jalen Love and Cam Griffin each added 10 points.
Guard Aaron Bright, who missed the previous four games, played 15 minutes off the bench and hit his first 3-pointer of the season after 13 misses.
Powell, who scored 19 in the first half, made his first six shots in helping the Cardinal to a 35-19 halftime lead.