Nicole Griffin added 18 points, and Joanna McFarland had 12 rebounds for the Sooners (9-2). Morgan Hook had six assists.
Oklahoma led 32-22 at halftime and never trailed. The Sooners shot 42 percent from the field for the game, while the Highlanders shot 31.7 percent.
Tre'Shonti Nottingham led the Highlanders with 14 points and eight rebounds. Natasha Hadley had 12 points and six rebounds for the Highlanders (6-4).
Attendance at the game was listed as 5,516.
Oklahoma and UC Riverside have met once previously. The Sooners defeated the Highlanders 88-57 in 2008.