The home on Leadwell Street had been dubbed "Fort Hernandez" by the Hernandez family and members of Occupy San Fernando Valley, who protested what they called unfair practices by banks.
Following a foreclosure notice earlier this year, one family member, Ulises Hernandez, said he would resist nonviolently and would not leave the home voluntarily when deputies came for the eviction.
But when Los Angeles County deputies showed up about 5 a.m. today, everyone cooperated, sheriff's spokesman Steve Whitmore said.
"It was very smooth," he said.
Whitmore said the Sheriff's Department was prepared for some resistance, having known about the protests and the plywood fence Occupy L.A. put up.
Six to eight family members were living in the house, and 10 to 12 others were staying in tents on the lawn. There also were five dogs at the home, Whitmore said.
Ulises Hernandez could not immediately be reached on his cell phone this morning.
His brother, Javier Hernandez, bought the home in 2006 and lived there with relatives. In an interview earlier this year, he said he signed a subprime mortgage, whose terms included interest-only payments up front and an adjustable rate.
After the payment went from $3,900 to $4,500 in 2008, the Hernandezes stopped paying. The last payment was made in February 2008.
The Hernandezes said they weren't expecting to live there for free, but had sought four loan modifications and been denied each time.
In retrospect, they said the mortgage was a bad deal.
"We didn't know exactly what we were getting ourselves into," Ulises Hernandez said in August.
A Bank of America spokeswoman said Javier Hernandez was given several chances to modify the loan. At first, he didn't submit some required documents. Later, the bank found he did not qualify for a modification.
The "Fort Hernandez" sit-in began this year after a notice of eviction in August.
During a reporter's visit this fall, the Hernandez brothers and supporters they met through the Occupy movement kept watch 24 hours a day on a scavenged assortment of couches sitting on the lawn or street. Behind them sat anti-bank and anti-Wall Street protest signs.