Ridden by Hall of Famer Gary Stevens, Great Hot ran 1 1/16 miles in 1:43.08 and paid $20.80, $5.60 and $3.40. It was Stevens' fifth win in the race, having won it for the first time in 1988.
"At the three-eighths pole I let her out a notch and it wasn't full-tilt yet, but it was enough to get their attention," Stevens said of the other four horses. "When we turned into the stretch, she still had enough to hold the other filly (Book Review) off."
Stevens has won three straight stakes at Santa Anita, having swept a pair last weekend. The 49-year-old rider began a comeback last month after a seven-year layoff.
Book Review returned $2.80 and $2.10 as the even-money favorite for Hall of Fame trainer Bob Baffert. Lady of Fifty was another 3 3/4 lengths back in third and paid $2.80 to show.
The victory, worth $120,000, increased Great Hot's career earnings to $537,927, with five wins in 21 starts. The 5-year-old Brazilian-bred had been winless in her previous 13 starts.