Jorgensen, from St. Paul, Minn., completed the 1,500-meter swim, 40-kilometer bike and 10-kilometer run in 1 hour, 59 minutes, 59 seconds to also win her first USA Triathlon Elite National Championships title.
"It's a huge honor and I think it's only going to increase our athletes in the U.S.," Jorgensen said. "It's going to motivate and push other U.S. athletes as well. It's really exciting because it was on U.S. soil."
Britain's Non Stanford edged Australia's Emma Moffatt of Australia in a sprint for second, with both finishing in 2:03:03. Sarah Groff of Hanover, N.H., was seventh.