San Francisco police Sgt. Neville Gittens said the unnamed victim was taken by ambulance to San Francisco General Hospital after the 1:05 p.m. shooting at the end of the Interstate Highway 80 offramp and Fifth and Harrison streets.
The man suffered numerous gunshot wounds, including a shot to the chest, Gittens said.
Investigators do not believe it was a case of random violence.
`This appears to be a targeted shooting, based on the number of rounds fired,` Gittens said.
Witnesses watched in shock as the gunman got out of his vehicle and fired multiple shots into the victim's blue Dodge Charger.
One woman, who did not want to be named, said she was driving behind the Charger and a green vehicle and approaching the end of the ramp when traffic stopped at a light.
A man got out of the green vehicle and walked over to the Charger with a gun in his hand.
`He just opened fire until the light changed, then the green car sped up Fifth Street` toward downtown San Francisco, she said.
The victim's car remained in the middle of the intersection for hours Thursday afternoon, its rear window shattered and blood on the ground and in the vehicle, which was riddled with more than a dozen bullet holes.
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