Third-ranked Kansas State's perfect season remained intact Saturday night.
So did its national title hopes.
The future of both may be in jeopardy, though, after Heisman Trophy front-runner Collin Klein left in the third quarter of a 44-30 victory over visiting Oklahoma State because of an undisclosed injury.
Kansas State coach Bill Snyder declined to discuss the nature or severity of it afterward, and said he wasn't sure whether Klein would be available for next Saturday's game at TCU.
"Obviously he was injured or we wouldn't have taken him out," Snyder said.
Klein had thrown for 245 yards and run for 64 more before sneaking in for his 50th career rushing touchdown with 9:47 left in the third quarter to give Kansas State a 38-17 lead.
It wasn't clear when he got hurt, but Daniel Sams played the rest of the way.
"Without Collin at quarterback, we had to do some adjustments," said Tyler Lockett, who had a 100-yard kickoff return touchdown. "Collin was still a leader. He was on the sideline getting us going, especially when things weren't going our way. That's what I like about him."
Allen Chapman picked off three passes, returning one for a touchdown, and John Hubert added a pair of TD runs as the Wildcats (9-0, 6-0 Big 12) moved close to a Big 12 title and possibly the BCS title game. The Wildcats entered the weekend No. 2 in the BCS standings behind Alabama.
It was Kansas State's first victory
Rare home loss: Boise State entered its game against San Diego State with a 71-1 record in home games dating to 2001.
Now it's 71-2.
Adam Muema rushed for 127 yards and a touchdown and San Diego State's special teams had a hand in two other scores in a 21-19 victory over No. 19 Boise State.
Colin Lockett returned the opening kickoff for a touchdown, then in the third quarter Dwayne Garrett reached over a blocker and deflected Trevor Harman's punt to set up another score.
The Aztecs (7-3, 5-1 Mountain West) held on for the win when the Broncos (7-2, 4-1) scored a touchdown to pull within two points late in the game but were unable to convert a 2-point try.
Buckeyes cruising: Although ineligible to go to a bowl game, No. 6 Ohio State moved closer to an undefeated season with a 52-22 rout of visiting Illinois.
Carlos Hyde rushed for 137 yards and three touchdowns, and Braxton Miller passed for two scores and ran for one as the Buckeyes (10-0, 6-0 Big Ten) maintained their upper hand in the Leaders Division heading into a bye week. They have games remaining at Wisconsin on Nov. 17 and against rival Michigan at home a week later.
It was the sixth consecutive loss for the Illini (2-7, 0-5) and their 11th in a row in the Big Ten.
Stoops moves up: Landry Jones threw for 405 yards and a four touchdowns, and No. 14 Oklahoma beat Iowa State 35-20, moving coach Bob Stoops into a second-place tie with Bud Wilkinson on the Sooners' career win list.
Stoops posted his 145th victory with Oklahoma. He is 12 wins shy of tying Barry Switzer for the most in school history.
Oklahoma (6-2, 4-1 Big 12) bounced back from a loss to Notre Dame. The Sooners have won 20 straight following a defeat in the regular season.
Iowa State (5-4, 2-4) lost its 21st straight home game against the Sooners, a stretch of futility that dates back 52 years.
Aggies roll: Johnny Manziel and the Texas A&M Aggies shredded another Southeastern Conference defense.
The redshirt freshman picked apart Mississippi State by completing 30 of 36 passes for 311 yards and danced around the No. 17 Bulldogs for 129 yards rushing and two touchdowns, leading the 16th-ranked Aggies to a 38-13 victory.
Texas A&M (7-2, 4-2 SEC) has won all five of its road games this season. Mississippi State (7-2, 3-2) has lost two in a row.
Wolverine switch: Devin Gardner replaced Denard Robinson in a surprise quarterback switch by Michigan right before kickoff, throwing two touchdown passes and running for another score to lead the Wolverines past Minnesota 35-13.
Gardner woke up the Wolverines (6-3, 4-1 Big Ten) after they went two straight games without a touchdown, guiding scoring drives of 91, 90, 86 and 79 yards to squash the hope the Gophers (5-4, 1-4) had of an upset with Michigan's senior star on the sideline. Robinson has been bothered by nerve damage in his right elbow.
Minnesota hasn't beaten Michigan at home since 1977.