Coming off an impressive debut nearly three weeks ago, Webster was hammered by Minnesota on Wednesday night, recording just five outs while surrendering eight runs on six hits as the Red Sox were pounded 15-8 by the Twins.
The 23-year-old right-hander was recalled from Triple-A Pawtucket on Tuesday and expectations were high after he allowed two earned runs and five hits in six innings against Kansas City on April 21.
After striking out the first batter of the game, it quickly turned sour. Webster (0-1) walked the next two batters before Ryan Doumit belted a two-run home run.
"I fell behind, didn't make my pitches," Webster said, "and then when I did make my pitches, they made me pay."
Jonny Gomes hit a grand slam in the bottom of the first as Boston jumped in front 5-4, but Webster was tagged for four more runs and was chased in the second.
"The team did all they could to help me out," said Webster, who walked three and struck out two. "I just went back out there and if I had thrown a zero we'd probably win the game, but I didn't."
Location and command were both lacking, said Red Sox manager John Farrell and pitching coach Juan Nieves.
"Right from the start, just the inability to establish a certain pitch to a given area to get a strike when needed and when he got behind in the count, then he's obviously at a disadvantage," Farrell said.
Pedro Florimon had a solo homer and a two-run double in Minnesota's season-high, seven-run second inning that carried the Twins to their second straight win over Boston.
David Ortiz went 0 for 5 with two strikeouts and three groundouts to snap his 27-game hitting streak, dating to last season. Ortiz had hit safely in his first 15 games this season, giving him Boston's longest since Manny Ramirez also hit in 27 straight in 2006.
Oswald Arcia went 4 for 5 with three singles and a double, and Trevor Flouffe drove in three of the Twins' season-high runs. Minnesota also had a season-high 20 hits.
Jonny Gomes drove in five runs and Shane Victorino added a solo homer for Boston, which lost for the fifth time in six games.
In the first two innings, the teams combined for 17 runs and 10 extra-base hits, chasing both starting pitchers as the Twins held an 11-6 edge after posting their big second inning.
Ryan Pressly (1-0) pitched four shutout innings of relief for the win.
Twins starter Pedro Hernandez faired just a little better than Webster, allowing six runs and seven hits in two innings of his fifth career start.
Trailing 5-4 in the second, Minnesota sent 11 batters to the plate and had its biggest inning of the season. Florimon tied it with a leadoff homer into the seats above the Green Monster. Justin Morneau's sacrifice fly pushed the Twins ahead, before Plouffe's RBI double chased Webster. Aaron Hicks then had a two-run single off Felix Doubront and Florimon followed with his two-run double, making it 11-5.
Victorino's homer into the left-field seats cut it to 11-6 in the bottom of the second.
Minnesota added a run in the fourth on Florimon's double-play grounder. Plouffe delivered a run-scoring single and Arcia collected his fourth hit of the game in the fifth—an RBI double—to make it 14-6.
After Webster fanned Jamey Carroll to start the game he walked the next two before Morneau's RBI double. Plouffe followed with a sacrifice fly before Doumit homered into Boston's bullpen.
Boston responded by taking the lead with five runs after two outs in the bottom of the inning. Gomes belted his slam over the Monster and completely out of Fenway Park after the Red Sox loaded the bases with a pair of singles and a walk. Stephen Drew's RBI single made it 5-4.
NOTES: Ortiz's personal season-opening streak is the best by a Red Sox player since Tony Pena also hit in his first 15 in 1990. ... The Red Sox honored Orlando Cepeda (Boston) and Ron Blomberg (Yankees) during a pregame, on-field ceremony for the 40th anniversary of the DH. Current Red Sox DH Ortiz handed them each commemorative framed pictures. ... Farrell said 3B Will Middlebrooks had an MRI on his right side after bruising his ribs making a sliding grab of a foul pop before colliding with C David Ross in Tuesday's loss. "He's banged up a little bit," Farrell said. He expects Middlebrooks to play Thursday. ... Farrell also said Ross still had "some soreness" in the left quadriceps. ... The Twins close out their 10-game road trip Thursday when Kevin Correia (3-2, 2.83 ERA) is slated to face Boston's John Lackey (1-2, 3.52) is the series finale.