The Pride scored 32 points in the first half and rolled past the host Dons in a nonleague game. Salesian added a touchdown in the third quarter.
Michael Page had 180 yards rushing and four touchdowns to lead the Pride.
Salesian is coming off one of the most impressive seasons in program history, as it went 13-0 and won the North Coast Section Division IV championship. The Pride averaged over 42 points per game in 2011 and allowed less than 10 points per contest.
De Anza's program took a step forward last season. The Dons' two regular season wins in 2011 were the most by the program in one year since 2007, when they went 3-7.
Salesian plays at Middletown next Friday, and De Anza hosts St. Elizabeth on Sept. 7.