St. Louis Rams quarterback Sam Bradford has a torn anterior cruciate ligament in his left knee for the second straight year and is out for the season.
Coach Jeff Fisher confirmed the extent of the injury Sunday night.
"We lost our quarterback," Fisher said. "For Sam, it was devastating."
Bradford was injured in Saturday's 33-14 exhibition win at Cleveland. He was hit on his left side by Armonty Bryant as he threw a pass.
Bradford, the first overall pick of the 2010 draft out of Oklahoma, also missed the last nine games last season.
Veteran Shaun Hill is the backup, and the Rams also have rookie Garrett Gilbert and Austin Davis on the roster.
"Shaun's our guy," Fisher said. "I brought him here."
Also, cornerback Trumaine Johnson will be out four to six weeks with a medial collateral ligament tear in his knee.
Panthers: Cam Newton has a hairline fracture in his ribs. Coach Ron Rivera said his starting quarterback was out for Thursday's game at Pittsburgh but expects Newton to play in the season opener at Tampa Bay on Sept. 7. But Rivera later referred to Newton's status as "week to week." Newton was injured while scrambling in Friday's loss at New England. He was wearing a flak jacket, but Rivera said Newton was struck in the crease of the jacket. Newton is also coming off offseason ankle surgery.
Broncos: Receiver Wes Welker suffered a concussion after taking a hit to the head from Houston's D.J. Swearinger on Saturday. Swearinger, who drew an unnecessary roughness penalty, said Welker "ducked his head. I went with his shoulder. What am I supposed to do?" Welker has a history of concussions.
Packers: Nose tackle B.J. Raji and center JC Tretter are out indefinitely. Coach Mike McCarthy confirmed Raji suffered a significant biceps injury in Friday's victory over the Raiders. Raji is expected to miss the season. Tretter sustained a significant knee injury.
Jets: New York released six players, including former Raiders wide receiver Jacoby Ford.
Dolphins: Hall of Fame quarterback Dan Marino was named special adviser to owner Stephen Ross. Marino spent the last decade as an analyst for CBS.
Bills: Buffalo released veteran defensive lineman Alan Branch a day after he was arrested for drunken driving.
Bears: Chicago cut Jordan Palmer, making Jimmy Clausen the backup quarterback behind Jay Cutler.
The Charlotte Observer contributed to this report.