Not long after Bob Reed learned in 1986 that he had AIDS, he watched 20 of his friends die from the disease as it ravaged his body and he battled to survive.
Today, as he sits in his Saratoga home feeling better than he has in years, he ponders a question no one can answer.
"Why did I make it and other people didn't?" he asks. "There's a part of me that has a little bit of survivor guilt."
As the epidemic enters its fourth decade, the 57-year-old Saratoga resident is among a growing number of people who are living with HIV or AIDS into their 50s, 60s, and beyond, surviving with a new generation of medications that have greatly increased life expectancy.
Before the mid-1990s, three-quarters of people infected with HIV, the virus that causes AIDS, died within 10 years. Now, for those who get early diagnosis and prompt treatment, nearly normal life spans are possible.
About 1.1 million American adults and teenagers were living with HIV infection in 2009, and 17 percent of them were 55 or older, according to the latest estimate.
Still, aging with HIV has unique health challenges. Some people grapple with chronic conditions typically seen in those who are 20 years older -- heart disease, bone loss and kidney damage. Others deal with premature aging of an immune system that has fought the infection for years.
And scientists are just beginning to explore the long-term effects of a complex cocktail of HIV medications, including how they interact with other drugs that aging people often take.
Despite the challenges, many who have worked with HIV-infected people for years -- and seen so many die -- say aging with AIDS is survival.
"This is a wonderful problem to have," said Alvan Quamina, executive director of AIDS Project East Bay.
Reed spent nearly half of his life assuming he was about to die.
He had a stroke in 1994 and now has heart disease that led doctors to install two stents in his arteries.
His toughest year came in 2005 when a painful stomach infection caused him to vomit almost daily and the 6-foot-1 former nurse's weight dramatically dropped to 130 pounds. He had a feeding tube in his chest for months.
"He spent much of the year near death," recalled Phil Hofford, his partner of 21 years. "We were pretty much making final plans a couple times during that period."
It wasn't until 2009 that a newly available medication resolved his stomach infection, "and saved my life," Reed said.
In November, he felt well enough to start working again. He now does HIV test counseling at the Billy DeFrank LGBT Community Center in San Jose and weighs a healthy 182 pounds.
"He's coming back to life," Hofford said. "Suddenly, he's waking up like Rip Van Winkle."
Yet their home is a constant reminder of the ravages of the disease.
Its previous owner took in people who had AIDS during the early days of the epidemic. More than 20 people died in the single-story house near the San Jose border. But Reed and Hofford consider living there uplifting.
"To me, it's pretty awe-inspiring to know what was going on in that house," Hofford said. "There has been more love in that house for the people that passed on than most houses see in a lifetime."
Reed said he has no idea why he survived when so many others did not.
"Whenever my T-cells (white blood cells that help the body fight disease) were the lowest and hope was the least, a new medication would come out," he said. "I'm just one of the luckiest people I know."
Those who look at Joey Wever these days would never guess he has HIV.
The 63-year-old Oakland resident learned he was infected in 1996, after an eye doctor noticed his eyes were damaged and asked if he had been given an AIDS test.
"I lost about 40 percent of my peripheral vision on the right side," said the former X-ray and ultrasound technician.
Wever vividly remembers driving home after testing positive and thinking he had maybe five more years.
He was bedridden for nearly a year and neuropathy damaged his hands.
But by 2000, he had improved enough to take a full-time job with the city of Berkeley as a social worker for Meals on Wheels. He was so busy, however, that he neglected his regimen of pills every eight hours.
He developed a resistance to the medications and at 5 feet 8, watched his weight plummet from 155 pounds to 128.
"I saw my reflection on glass and I even scared myself," he said.
His doctor changed his medications and his health improved, but his life really turned around when drugs known as protease inhibitors came out.
"I feel so energetic and I'm more involved in the community," he said during a recent interview in his Fruitvale district apartment in Oakland as his four colorful lovebirds chirped away.
Today, Wever cares for his ailing 95-year-old mother, does volunteer work with a number of health and community organizations, and is active in El Grupo, a support group for Latinos with HIV.
His good friend Faye Combs has watched his transformation. She was taken aback by how healthy he looked about a year ago.
"I said, 'Boy, you are a handsome dude,'" she said. "He had put the weight back on and he just looked great. He just doesn't give up."
To keep his infection in check, Wever takes four pills together, twice a day -- a big improvement from a thrice-daily regimen that often sickened him.
The medications for those infected with HIV have greatly improved, but questions remain about the long-term effects.
"Most of the studies were initially done on much younger patients because that's who was more likely to be infected," said Dr. Michael Horberg, Kaiser Permanente's national director of HIV/AIDS.
"So we don't know how all the antiretrovirals are going to work as patients get older and have been on these meds cumulatively many more years."
The epidemic is by no means over: In 2011, nearly 50,000 new HIV infections were identified in the United States and more than 32,000 people were newly diagnosed with AIDS, according to the latest national Centers for Disease Control and Prevention report.
The early aging of people with HIV may not lead to more gray hair and wrinkles, but it becomes apparent in their blood and immune systems, said Dr. Mark Holodniy, an infectious disease professor at Stanford University and director of public health surveillance for the Department of Veterans Affairs.
"And even when people are on effective treatment and controlling the virus," Holodniy said, "there is still an ongoing inflammatory response in the body that seems to wreak havoc. Some of the problems that you might expect in people that are 60 or 70 years old, you're now seeing in people that are 40 or 50."
Advocates urge the public not to forget the older generation, even as attention and resources are devoted to preventing HIV infection among the young.
Now that they are feeling healthier, Wever and Reed must decide what to do with the rest of their lives.
"I never expected to be around this long," Wever said. "Now, how do I live with what I have left? We're going to be around, and hopefully we'll be able to contribute."
Sandy Kleffman covers health. Contact her at 510-293-2478. Follow her at Twitter.com/skleffman.