Making his 21st career start against Milwaukee, Marquis found trouble right away. He gave up a two-run homer to Ryan Braun and a three-run shot to Yuniesky Betancourt in the first inning, and the Brewers handed the San Diego Padres their sixth straight loss at home, 7-1 Monday night.
Marquis allowed a season-high seven runs in four-plus innings and a season high-tying four walks. He also hit two batters, both of whom scored on Betancourt's longball.
Marquis (1-2) is 6-12 lifetime against the Brewers, his most losses to any team.
"They (Brewers) were really aggressive in the counts in that first inning," said catcher Nick Hundley. "He got a couple of the pitches a little up."
Marquis said: "I made some bad pitches ... and it's very frustrating."
Kyle Lohse (1-1) went five innings, allowing one run and five hits, but left in the sixth after dislocating his pinkie when he caught the finger on the elbow of Padres second baseman Jedd Gyorko, who was covering first, after an unsuccessful sacrifice bunt. Lohse struck out four and walked one.
"Kyle's OK," Brewers manager Ron Roenicke said. "They put it back in and X-rays were negative and we think he'll be OK for his next start."
Lohse has experience with this type of injury.
"I've done it a couple of times, always in the off season," he said. "It will be fine.
The homer for Braun was his sixth of the season. He also had an RBI single in the fifth and has 19 RBIs.
In his last visit to Petco Park, Braun became the first player to hit three home runs in one game at the ballpark. He also had a triple in his last at-bat here on April 30, 2012. He has five homers and 13 RBIs in 16 games at Petco.
"I just enjoy coming back to the West Coast," Braun said. "It's always rejuvenating for me. Obviously (Petco Park) is still a challenging ballpark to hit but I've enjoyed hitting here throughout the course of my career, and as a team I think we've enjoyed getting a chance to come here and play."
Betancourt's home run, his third, came after Marquis had hit consecutive batters—Logan Schafer and Carlos Gomez—with two outs.
"He couldn't really get anything going in that first inning," Padres manager Bud Black said. "Braun jumped on a fastball that was meant to be down and away and it just sort of tailed to the middle of the plate."
The Brewers have hit 15 home runs in eight games after hitting five homers in their first 10.
Milwaukee had scored just five runs in Lohse's first three starts before putting up a five-spot in the first inning on Monday.
The Brewers added two more runs in the fifth, one on Braun's RBI single and they scored on a wild pitch by Padres reliever Anthony Bass with the bases loaded.
The Padres, who were shutout in San Francisco Saturday and Sunday, snapped their 25-inning scoreless streak with a run in the fifth on a double by Gyorko and an RBI fielder's choice by Bass.
NOTES: Padres OF Carlos Quentin, who served the last game of his eight-game suspension Monday for his part in the benches-clearing brawl in which Dodgers star Zack Greinke broke his collarbone, will be back in the Padres lineup Tuesday. ... Padres 1B Kyle Blanks wasn't in the starting lineup, but was available for pinch-hitting duty Monday night, a day after sustaining a cut on his left eyelid when he was cut by his sunglasses as he smacked into the left field wall making a catch in the sixth inning at San Francisco. "I feel definitely better than yesterday," said Blanks. "It's going to be a kind of a touch and feel progression. I saw it (on replay) and it reminded me of how fun it wasn't, but my head feels good, neck feels fine, mainly it's just a lot of soreness in my shoulder." Black said that Blanks had stitches in his eyelid just below his eyebrow. ... Black also said that LHP Clayton Richard (0-1, 5.28) was feeling better after a stomach flu cancelled his start in San Francisco and that he would be on the mound Tuesday against Milwaukee's Yovani Gallardo (1-1, 5.24).