Taylor and co-driver Max Angelelli raced to their second straight victory in the No. 10 Wayne Taylor Racing Corvette DP to take an eight-point lead over the Chip Ganassi Racing duo of Pruett and Memo Rojas into the season finale Sept. 28 at Lime Rock Park in Connecticut.
Taylor also held off Pruett for the victory in the previous event at Kansas Speedway
"I definitely was under a lot more pressure at Kansas," said Taylor, who teamed with Angelelli to lead a race-high 72 laps. "Today we had a better car and we could control it from the front. It was a lot more comfortable this weekend."
Dixon and fellow IndyCar driver Dario Franchitti teamed to finish third in Ganassi's No. 02 BMW Riley.
Andy Lally and John Potter won the GT class for their first victory of the year and finished 16th overall, driving the No. 44 Magnus Racing Porsche GT3 Cup to the points lead.
"This was my longest slump without a victory that I've had as a Rolex Series driver," Lally said. "To win in a clutch moment in the penultimate round of the season was massive."
In GX, Sylvain Tremblay and Tom Long race to their third victory of the season in the No. 70 MazdaSpeed/Speedsource Mazda 6.