Jaquon Parker set a season high with 21 points, and Sean Kilpatrick added 15 points and 10 rebounds for the Bearcats (4-0), who never trailed and led by as many as 25.
Cincinnati is scheduled to play its first road game Friday against Iowa State as the GSI continues in Las Vegas.
Darren White, who came in leading the Big South Conference with 25.5 points per game, bounced back from scoring just three in the first half to finish with 22 for Campbell (2-3).
Trey Freeman scored a season-high 17 for the Fighting Camels, the preseason favorite in the Big South's North Division, while Darian Hooker added 13 and Reco McCarter finished with 10.
The Bearcats dominated inside, outrebounding Campbell 50-28 and finishing with nine blocked shots to Campbell's two.
But Cincinnati continued to struggle with free throws. The Bearcats, who were shooting 53.3 percent (40 of 75) from the line coming in, went 18 of 34 (52.9 percent) in the first game between the two teams.
Wright, whose previous career high was 25 in a 101-70 win over Radford last Dec. 17, scored 13 and Parker added 11 to lead Cincinnati to a 46-28 halftime lead.
Cincinnati never trailed after Wright made the first of two consecutive 3-pointers to snap a 2-2 tie with 17:30 left in the first half.
Parker gave Cincinnati a 21-point lead twice, the first on a 3-pointer from the left corner with 6:35 left before halftime and the second with a driving layup along the right baseline with 4:36 remaining.