Drew Brees passed for 413 yards and four touchdowns, and the host New Orleans Saints turned a clash of unbeaten teams into a lopsided affair, beating the Miami Dolphins 38-17 on Monday night.
"I felt like we found our rhythm," Brees said. "Every time we touched the ball, it felt like we were going to go down and score points."
Two of Brees' touchdowns went to Jimmy Graham for 27 and 43 yards as the tight end had at least 100 yards receiving for the third straight game.
The Saints are 4-0 for the first time since their Super Bowl championship season of 2009.
Ryan Tannehill passed for 249 yards and a touchdown to Charles Clay, but his four turnovers on a fumble and three interceptions hurt Miami (3-1).
The Saints have won their last nine Monday night games, all with Brees at quarterback.
When Brees was a free agent in 2006, he drew the most interest from New Orleans and Miami, but the Dolphins, fearful of reconstructive surgery on Brees' throwing shoulder, did not pursue the quarterback as enthusiastically as Saints coach Sean Payton.
Buccaneers: Safety Dashon Goldson will not be suspended but might be fined for his hit on Arizona Cardinals receiver Jaron Brown in Sunday's game. Merton Hanks, the league's vice president of football operations, said the play is being re-examined for a helmet-to-helmet hit but that it won't warrant a suspension.
Freeman said in a statement released by his agent that he has passed all 46 drug tests he's taken for the league since once using Ritalin instead of Adderall to treat ADHD.
Titans: Coach Mike Munchak says quarterback Jake Locker needs more tests on his injured hip and that he doesn't know how long Locker will be out. Still, Munchak is optimistic Locker will be back this season. Munchak said Locker also sprained his right knee on the hit Sunday.
Patriots: Defensive tackle Vince Wilfork has a torn right Achilles tendon and is likely out for the season, a league source confirmed to ESPN.com.
Browns: Coach Rob Chudzinski said quarterback Brian Hoyer will start Thursday's game against Buffalo. Hoyer has gone 2-0 since replacing injured starter Brandon Weeden (sprained thumb). Chudzinski said Weeden is healthy and cleared to play.