De Anza running back Dontae Ward scampered four yards after a lateral from quarterback Stephen Evans and scored the game winning touchdown with 24 seconds left, to help the Dons (1-2) break a 42-game losing streak.
The Dons held a 14-0 lead at the half, but Albany (1-2) came storming back in the second half, behind the running of Kyle Moore.
Moore, who had just three yards in the first half, broke loose for 132 yards in the second half and scored two touchdowns. He scored on a 3-yard run in the third and a 45-yard sprint up the middle in the fourth. The latter came with Albany trailing 21-14 with just 1:36 left in the game.
After the score, Albany was successful on a two-point conversion (a Moore run) to give them a 22-21 lead. But an excessive celebration penalty on Albany forced them to kick off from their own 25-yard line and De Anza took over at their own 46 with 1:29 remaining.
On the Dons first play, Evans connected with George Mann on a 49-yard pass play for a first down at the 6. Three plays later, Evans rolled out, and after gaining two yards pitched the ball to Ward who finished the run for the winning touchdown.
Albany's last gasp pass attempt was intercepted (De Anza's fifth of the game), sealing the long awaited win for the program under first-year head coach Jim Klaczak.
De Anza dominated the first half of play behind running back Andre Dunn's 133 yards. He scored on a 6-yard run in the first and Evans scored on a 26-yard scramble in the second quarter.
Albany was held to just 19 yards on the ground in the first half while De Anza ran wild for 180 yards. The second half was a complete reversal as Albany chalked up 138 yards and De Anza managed just 73 (72 coming on five fourth quarter carries by Ward).